Endocrine Abstracts

Introduction: Incidence of Digestive NETs (DNETs) has increased in the last 40 years. Visceral obesity, metabolic syndrome (MetS) and insulin resistance (IR) have been associated with several types of cancer.Aim: To evaluate possible associations of obesity, hyperinsulinemia and IR with well-differentiated (WD) DNETs through a case control study.Materials and methods: Ninety-six patients with gastrointestinal (75.0%) and pNET (22.9...

The androgen receptor (AR) plays a pivotal role in prostate cancer development, progression and hormone-therapy resistant disease. AR requires a permissive epigenetic state at distinct chromatin regions to facilitate gene expression programs. The vast majority of AR sites are found at active enhancer regions, hallmarked by histone modification H3K27Ac and devoid of repressive markers including H3K27me3. In search for novel biomarkers for prostate cancer prognostication, we per...

Introduction: Primary thyroid lymphoma (PTL) is responsible for 0.6–5% of all cases of thyroid cancer and less than 2% of all extranodal lymphomas. PTL is more common in elderly women and are commonly of B-cell origin. Current treatment regimens for PLC consist of chemotherapy and external beam radiation. Surgery plays an important role, including the control of symptoms in large obstructive lymphomas.Aims and methods: Retrospective data review of p...